Impact of a Plasmodium falciparum AMA1 Vaccine on Antibody Responses in Adult Malians

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Impact of a Plasmodium falciparum AMA1 Vaccine on Antibody Responses in Adult Malians

BACKGROUND Apical Membrane Antigen 1 (AMA1) of Plasmodium falciparum merozoites is a leading blood-stage malaria vaccine candidate. Protection of Aotus monkeys after vaccination with AMA1 correlates with antibody responses. STUDY DESIGN/RESULTS A randomized, controlled, double-blind phase 1 clinical trial was conducted in 54 healthy Malian adults living in an area of intense seasonal malaria ...

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ژورنال

عنوان ژورنال: PLoS ONE

سال: 2007

ISSN: 1932-6203

DOI: 10.1371/journal.pone.0001045